Evidence supporting the use of: Proanthocyanidins
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proanthocyanidins, a class of polyphenolic compounds found in foods such as grapes, berries, and cocoa, have been investigated for their potential benefits in supporting bone health, including osteoporosis. Some laboratory and animal studies suggest that proanthocyanidins may exert positive effects on bone metabolism. Specifically, they have been shown to possess antioxidant and anti-inflammatory properties that could potentially inhibit bone resorption (the breakdown of bone tissue) and stimulate osteoblast (bone-forming cell) activity. For example, studies in ovariectomized rats—a common animal model for postmenopausal osteoporosis—have reported that supplementation with proanthocyanidins can reduce bone loss and improve bone microarchitecture. Additionally, in vitro studies indicate that proanthocyanidins may modulate signaling pathways involved in bone turnover. However, clinical evidence in humans is very limited. To date, there are few, if any, well-designed randomized controlled trials directly evaluating the effect of proanthocyanidin supplementation on bone mineral density or fracture risk in humans with osteoporosis. Most of the supportive data come from preclinical research, and these findings have not yet been robustly translated into clinical practice. Therefore, while there is a scientific rationale and some promising preclinical evidence, the overall strength of evidence is currently low (rated 2 out of 5), and proanthocyanidins should not be considered a proven treatment for osteoporosis at this time.

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