Evidence supporting the use of: Pomegranate
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pomegranate (Punica granatum) has attracted scientific interest for its potential role in supporting bone health, including osteoporosis, due to its rich content of polyphenols, flavonoids, and other bioactive compounds. Several preclinical studies (using animal models and in vitro systems) have suggested that pomegranate extract may help in reducing bone loss associated with osteoporosis. For instance, research has shown that pomegranate juice or extract can inhibit osteoclast differentiation and activity, thereby reducing bone resorption. Additionally, some studies indicate that the antioxidant and anti-inflammatory properties of pomegranate may counteract the oxidative stress and inflammation that contribute to bone degeneration.

However, direct evidence from human clinical trials is currently limited. Most of the available data are from laboratory or animal studies, not from large, well-controlled trials in people with osteoporosis. While traditional medicinal systems have used pomegranate for various health issues, its use specifically for osteoporosis is primarily supported by emerging scientific research rather than long-standing tradition. As such, the rating for the strength of evidence is 2 (weak-to-moderate), reflecting promising but preliminary findings. Individuals interested in using pomegranate for bone health should consult healthcare professionals and not rely on it as a sole treatment for osteoporosis.

More about pomegranate
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Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
Alfalfa
algal oil
alpha-ketoglutarate (AKG)
anthocyanins
ashwagandha
astragalus
beta caryophyllene
sesame
blueberry
boron
bovine
broccoli
calcium
catechins
caterpillar mushroom
Cissus quadrangularis
collagen
collard
conjugated linoleic acid (CLA)
curcumin
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish protein
genistein
genistin
glycitin
gooseberry
hesperetin
hesperidin
horsetail
ipriflavone
knotweed
kale
Lentinula edodes mycelia
lignans
maca
magnesium
manganese
Microcrystalline hydroxyapatite concentrate (MCHC)
olive
omega-3 fatty acids
phosphorus
pomegranate
prune
quercetin
rehmannia glutinosa
resveratrol
rutin
silicon
soybean
specialized pro-resolving mediators (SPMs)
strontium
tocotrienols
vitamin C
vitamin D
vitamin D3
vitamin K
seaweed
Whey protein
Zinc
red clover
haliotis
cistanche
dioscorea
fern
royal jelly
equol (proprietary)
barrenwort
goji berry
AMP-activated protein kinase (AMPK)
soy isoflavones
8-Prenylnaringenin
animal Tissue
antler
apigenin
Algas calcareas
Acacetin
astragaloside
ampelopsin
Algal protein
Algalin
Abalone
arctiin
astragalin
animal protein
bok choy
bovine protein
biochanin
bone protein
calycosin
cod liver oil
cyanidin
Chinese Ligustrum berry
DHEA
daidzein
diosgenin
Drynaria
diosmetin
epicatechin
ecdysteroids
eicosapentaenoic acid
Eucommia ulmoides
estrogen
fo-ti
formononetin
fish
flavanones
flavans
flavanols
flavones
Hyperoside
isoflavones
icariin
Kaempferol
Lycium
Lithothamnion
Legume protein
Mineral blend
Marine protein
Milk Protein
Naringenin
Neoeriocitrin
Puerarin
Phytoecdysteroid
Phaeophyceae
polysaccharides
procyanidin
proanthocyanidins
polyunsaturated fat
paeoniflorin
Phytoestrogens
polymethoxylated flavones
Rehmannia
Soy
Soy Protein
silica
Shilajit
Stilbenoid
Ursolic Acid
Vegetable Protein
Wakame
Xanthophyll