Evidence supporting the use of: Isoflavones (mixed)
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isoflavones, particularly those derived from soy, have been studied for their potential role in supporting bone health and preventing osteoporosis, especially in postmenopausal women. Isoflavones are phytoestrogens—plant-derived compounds with estrogen-like activity. Since estrogen deficiency after menopause accelerates bone loss and increases osteoporosis risk, it has been hypothesized that isoflavones could mitigate bone loss by exerting weak estrogenic effects on bone tissue. Several randomized controlled trials and meta-analyses have investigated this effect. Some studies suggest that isoflavone supplementation may modestly improve bone mineral density (BMD) or slow bone loss, particularly in the lumbar spine of postmenopausal women. However, the overall magnitude of the effect is small, and results are inconsistent across studies. The quality of the evidence is moderate, and the clinical relevance is still debated. Systematic reviews, such as a 2019 Cochrane review, conclude that while there may be a slight benefit, isoflavones should not replace conventional osteoporosis therapies. The most robust evidence exists for soy isoflavones (like genistein and daidzein), rather than isoflavones from other sources. In summary, there is some scientific evidence supporting the use of isoflavones for osteoporosis, but it is limited in strength and does not warrant them as a primary therapy.

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Products containing Isoflavones (mixed)

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