Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperetin is a flavonoid found predominantly in citrus fruits and has been investigated for various health benefits, including its potential role in supporting bone health and treating osteoporosis. The scientific interest in hesperetin for osteoporosis arises mainly from preclinical studies. Several animal and in vitro studies have shown that hesperetin can positively affect bone metabolism. It appears to enhance osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) differentiation, which are key processes in maintaining bone density. Mechanistically, hesperetin has been shown to modulate signaling pathways such as the estrogen receptor, BMP, Wnt/β-catenin, and RANKL/OPG pathways, all of which are critical in bone remodeling and homeostasis. Additionally, its antioxidant and anti-inflammatory properties may help protect bone tissue from oxidative damage and chronic inflammation, both of which contribute to osteoporosis progression.

Despite these promising findings from laboratory research, there is a lack of robust clinical evidence in humans. No large-scale randomized controlled trials have confirmed the efficacy of hesperetin supplementation in preventing or treating osteoporosis in people. Therefore, while the scientific rationale and preclinical data provide some support (hence a rating of 2), the absence of human data means hesperetin is not yet a validated or widely used therapy for osteoporosis in clinical practice.

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