Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bone protein, particularly bone morphogenetic proteins (BMPs), has been studied for its role in bone formation and regeneration. BMPs are a group of growth factors known to stimulate bone growth and repair by promoting the differentiation of mesenchymal cells into osteoblasts, the cells responsible for forming new bone. The rationale for using bone-derived proteins in osteoporosis is based on their ability to enhance bone healing and possibly stimulate new bone formation in areas of bone loss.

However, the majority of clinical research involving bone protein therapies, especially recombinant human BMPs (such as BMP-2 and BMP-7), has focused on localized bone defects, spinal fusion surgeries, and fracture healing rather than systemic osteoporosis. While animal studies and limited early-phase human trials suggest that BMPs can stimulate bone formation, there is currently insufficient high-quality clinical evidence supporting the use of bone protein supplements or injections for generalized osteoporosis management. Most osteoporosis treatments in clinical practice rely on antiresorptives (like bisphosphonates) or anabolic agents (like teriparatide) rather than BMPs.

In summary, while there is a scientific basis for the potential of bone proteins to support bone health, robust clinical validation for their use in treating osteoporosis as a systemic disease is limited at this time, leading to a moderate-low evidence rating.

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