Evidence supporting the use of: Blueberry
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Blueberry (Vaccinium spp.) has attracted interest in the context of osteoporosis due to its rich content of polyphenolic compounds, particularly anthocyanins and other antioxidants. Several preclinical studies have investigated the effects of blueberry supplementation on bone health, primarily in animal models. For example, research published in journals such as Journal of Bone and Mineral Research (2010) demonstrated that blueberry supplementation in ovariectomized rats—a commonly used model for postmenopausal osteoporosis—resulted in increased bone mass and improved bone structure. The proposed mechanisms include the modulation of oxidative stress and inflammation, both of which contribute to bone loss, as well as the upregulation of bone-forming pathways such as Wnt signaling.

Despite these promising findings in animals, direct evidence from human clinical trials is very limited. There are currently few, if any, well-designed, large-scale studies evaluating blueberry supplementation for the prevention or treatment of osteoporosis in humans. Most scientific validation remains at the preclinical stage, and the translation of these results to human populations is not yet established. Blueberries are not traditionally used in folk medicine specifically for osteoporosis, but their general health benefits and antioxidant properties have been widely recognized.

In summary, while there is some scientific basis (primarily from animal studies) suggesting blueberries may have a positive effect on bone health, the evidence in humans is insufficient, and thus, the overall support for their use in osteoporosis is modest.

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algal oil
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alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
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anthocyanins
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apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
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boron
bovine
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broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
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cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
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dioscorea
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diosmetin
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Drynaria
ecdysteroids
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EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
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fish
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flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
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maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
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olive
omega-3 fatty acids
paeoniflorin
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phosphorus
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