Mineral blends are commonly used as dietary supplements to support bone health and manage osteoporosis. The scientific basis for their use centers on the established roles of specific minerals—primarily calcium, magnesium, phosphorus, and sometimes trace minerals like zinc, copper, and manganese—in bone metabolism and structure. Calcium is the most abundant mineral in bone, and its supplementation has been shown in numerous clinical trials to help reduce bone loss and fracture risk, especially in populations at risk of deficiency (e.g., postmenopausal women, older adults). Magnesium and phosphorus also contribute to bone mineralization, while trace minerals act as cofactors for enzymes involved in bone formation and remodeling.

Reviews and meta-analyses (e.g., National Osteoporosis Foundation, Cochrane reviews) generally support the use of calcium—often combined with vitamin D—for osteoporosis prevention and treatment, though results for fracture prevention are mixed and benefits are most pronounced in individuals with low dietary intake. There is less robust, but growing, evidence that adding other minerals (as in "mineral blends") may further support bone health, though clinical trials often focus on isolated nutrients rather than complex blends. Nonetheless, the logic and some supportive data for multi-mineral supplementation exist, especially in the context of inadequate dietary intake.

In summary, the use of mineral blends for osteoporosis is scientifically grounded, with the strongest evidence for calcium (with or without vitamin D), and moderate evidence for the supportive role of other minerals in bone health.