Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin A is recognized for its essential role in maintaining and repairing epithelial tissues, including the oral mucosa. Scientific studies have shown that Vitamin A is important in the process of wound healing, particularly due to its involvement in cellular differentiation, immune function, and the synthesis of glycoproteins necessary for epithelial integrity. In the context of oral surgery, adequate Vitamin A levels are associated with improved healing of oral mucosal wounds, prevention of infection, and potentially reduction in scar formation. Several in vitro and animal studies have demonstrated that Vitamin A supplementation can enhance re-epithelialization and modulate inflammation following oral surgical procedures. Some clinical review articles note the importance of ensuring sufficient Vitamin A intake in patients undergoing oral surgery, especially in populations at risk for deficiency (such as the elderly, malnourished, or those with malabsorption syndromes). However, robust, high-quality randomized controlled trials in humans specifically examining Vitamin A supplementation and oral surgical outcome are limited. Therefore, while the biological rationale and some supportive evidence exist, routine supplementation is generally not recommended for all patients unless a deficiency is identified. Over-supplementation may carry risks of toxicity. In summary, there is moderate scientific rationale and some evidence supporting Vitamin A’s role in oral surgery recovery, but direct clinical evidence remains limited.

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