Henna (Lawsonia inermis) has been traditionally used in some cultures as a remedy for nosebleeds (epistaxis). In Unani and some folk medicine systems, powdered henna leaves are sometimes applied externally to the forehead or used as a nasal plug to help stop bleeding. The rationale in these traditions is based on henna's supposed astringent and cooling properties, believed to constrict blood vessels and reduce bleeding.

However, scientific validation for these claims is extremely limited. The majority of available evidence comes from anecdotal reports and traditional medical texts, not from controlled clinical studies. A few in vitro studies highlight henna's antimicrobial and anti-inflammatory effects, but there is no direct research confirming its effectiveness or safety for treating nosebleeds in humans. Modern medical literature does not recommend or mention henna as a treatment for epistaxis. Therefore, while the traditional use is documented, the evidence supporting its efficacy is weak (rated 1 out of 5), and its safety—especially for internal use in the nasal cavity—has not been established.