Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lion’s mane mushroom (Hericium erinaceus) has garnered interest for its potential effects on the nervous system, particularly its use in supporting mental well-being and reducing symptoms such as nervousness and anxiety. The justification for its use is primarily based on emerging scientific research, though the evidence is still preliminary and not robust.

Preclinical studies have found that lion’s mane contains bioactive compounds, such as hericenones and erinacines, that stimulate the production of nerve growth factor (NGF) and support neurogenesis. Animal studies suggest these compounds may have anxiolytic (anxiety-reducing) effects, possibly by modulating inflammatory pathways and enhancing neuroplasticity.

Human evidence is limited but growing. A small double-blind, placebo-controlled trial in 2010 reported that postmenopausal women consuming lion’s mane cookies for four weeks experienced reduced feelings of anxiety and irritation compared to placebo. Some more recent open-label studies and case reports have echoed these findings, but the sample sizes are small, and the studies often lack rigorous controls.

Historically, lion’s mane has been used in traditional Chinese medicine for general health and cognitive support, but there is little direct ethnobotanical evidence specifically linking it to the treatment of “nervousness.” Overall, while preliminary scientific evidence supports a modest benefit in reducing nervousness, more high-quality clinical trials are needed to confirm its efficacy.

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