Polygonatum cirrhifolium (commonly known as Whorled Solomon's Seal) has a longstanding role in various traditional medicine systems, particularly in Ayurveda, Traditional Chinese Medicine (TCM), and Himalayan ethnomedicine. Historically, its rhizomes have been regarded as "Rasayana" or rejuvenative agents, valued for their adaptogenic and restorative properties. Within these traditions, it is sometimes recommended for conditions described as "nervous debility," "general weakness," or "exhaustion," which may correspond to what modern descriptions call "nervous exhaustion." The rationale for these uses is largely based on the herb's reputed ability to nourish the body, restore strength, and promote vitality.

However, there is a lack of direct scientific validation for its effects specifically on nervous exhaustion or similar neuropsychiatric conditions. Most of the documented uses come from ethnobotanical surveys or classical texts, not controlled clinical studies. Some modern pharmacological studies suggest that related Polygonatum species may possess adaptogenic, antioxidant, or neuroprotective properties, but these are preliminary and do not directly support its clinical use for nervous exhaustion in humans. Overall, the evidence supporting the use of Polygonatum cirrhifolium for nervous exhaustion is primarily traditional, with modest support from preclinical research, but lacking robust scientific validation.