Evidence supporting the use of: L-tyrosine
For the health condition: Nervous Exhaustion

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-tyrosine is an amino acid that serves as a precursor to important neurotransmitters such as dopamine, norepinephrine, and epinephrine—chemicals involved in mood regulation, alertness, and the stress response. The use of L-tyrosine for "nervous exhaustion" (often described as mental fatigue, burnout, or stress-induced cognitive decline) is primarily based on its biochemical role in replenishing catecholamines that may be depleted during periods of prolonged stress or exertion.

Scientific evidence, mainly from small randomized controlled trials and a number of laboratory studies, suggests that L-tyrosine supplementation may help mitigate cognitive decline and performance deficits during acute stressors such as sleep deprivation, cold exposure, or multitasking. For example, a review in Military Medicine (2013) and studies published in Brain Research Bulletin (1995, 1999) found that L-tyrosine can enhance working memory and cognitive flexibility under stressful conditions. However, research is limited by small sample sizes, short study durations, and a focus on acute, not chronic, stress. There is little evidence directly assessing its efficacy for long-term "nervous exhaustion" as seen in chronic burnout or clinical fatigue syndromes.

Therefore, while there is some scientific rationale and preliminary evidence for its use in acute stress-induced mental fatigue, robust clinical trials are lacking. The evidence is best rated as 2 out of 5, indicating limited scientific support for L-tyrosine in managing nervous exhaustion.

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