Evidence supporting the use of: Barbed Skullcap
For the health condition: Nervous Exhaustion

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Barbed Skullcap (most often referring to Scutellaria barbata or occasionally Scutellaria lateriflora) has a long history of use in traditional herbal medicine, particularly in North America and East Asia. In Western herbalism, "skullcap" (usually Scutellaria lateriflora) has been used for centuries as a nervine, believed to calm the nervous system, reduce anxiety, and relieve symptoms of nervous exhaustion. Traditional practitioners used skullcap in tinctures or teas for people suffering from chronic stress, insomnia, or nervous irritability. However, the specific reference to "Barbed Skullcap" is less common in Western traditions; it is more frequently listed in Traditional Chinese Medicine (TCM) as Ban Zhi Lian, where it is used for other indications (such as inflammation and cancer), not specifically for nervous exhaustion.

Scientific studies on Scutellaria lateriflora (American skullcap) have identified flavonoids like baicalin and wogonin, which may have mild sedative and anxiolytic properties in animal models. However, robust clinical trials in humans for the treatment of nervous exhaustion are lacking. For Scutellaria barbata, most research focuses on its anti-tumor and anti-inflammatory effects rather than on the nervous system. Thus, while there is a traditional basis—especially for American skullcap—the scientific evidence is weak to moderate, and more research is needed to confirm efficacy and safety for nervous exhaustion.

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