Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B2, also known as riboflavin, is scientifically recognized for its essential role in cellular energy metabolism and the maintenance of normal nervous system function. Riboflavin acts as a precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are crucial for oxidative energy production and various enzymatic reactions within cells, including neurons. Deficiency in vitamin B2 can lead to neurological symptoms such as numbness, tingling, and neuropathy, although these are relatively rare in developed countries due to adequate dietary intake.

Clinical evidence supports that riboflavin plays a role in the prevention and management of certain neurological conditions. Notably, riboflavin supplementation has been studied for its efficacy in reducing the frequency and severity of migraine headaches, particularly in adults. Several randomized controlled trials and meta-analyses indicate that high-dose riboflavin (typically 400 mg/day) may reduce migraine frequency, likely due to its role in mitochondrial energy production in nerve cells.

While direct evidence supporting riboflavin supplementation for general nerve health in the absence of deficiency is limited, its vital metabolic functions and the neurological symptoms observed in deficiency states provide a scientific basis for its use in supporting the nervous system. However, the evidence is stronger for specific conditions (like migraine) rather than broad neurological support.

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