Sphaeranthus indicus, commonly known as East Indian globe thistle or "Mundi," is a plant widely used in traditional Ayurvedic medicine. Its historical use includes applications as a nervine tonic, believed to help calm the mind, relieve anxiety, and support overall nervous system health. Ayurvedic texts and traditional practitioners have described its use in managing conditions like epilepsy, insomnia, and various nervous disorders. Preparations made from its flowers, leaves, and whole plant are incorporated in various polyherbal formulations intended for nervous system support.

Scientifically, there is a limited but emerging body of research. Some animal studies suggest that extracts of Sphaeranthus indicus may possess anxiolytic (anxiety-reducing), antidepressant, and neuroprotective activities. For example, experimental studies in rodents have demonstrated reduced anxiety-like behavior and some protection against chemically-induced seizures. These effects are thought to be mediated by flavonoids, sesquiterpene lactones, and other phytochemicals present in the plant. However, these studies are preliminary, small-scale, and mostly preclinical; robust human clinical trials are lacking.

In summary, the use of Sphaeranthus indicus for supporting the nervous system is primarily rooted in traditional medicine, with some initial scientific interest but insufficient high-quality evidence to fully validate these uses.