Phosphatidylserine is a phospholipid component found in high concentrations in the brain and nervous system, where it plays a key role in cell membrane integrity and signaling. Its use for supporting the nervous system is primarily justified by scientific evidence, particularly in relation to cognitive function and age-related memory decline. Several clinical studies have evaluated the effects of phosphatidylserine supplementation on cognitive performance. For instance, a number of randomized controlled trials have found modest benefits in memory, attention, and mental flexibility among older adults with mild cognitive impairment or age-associated memory loss. The European Food Safety Authority (EFSA) has reviewed these claims, noting that while some evidence exists, it is not sufficiently robust to warrant official health claims in the EU.

Research also suggests phosphatidylserine may reduce cortisol levels and improve subjective well-being following physical or mental stress, supporting its role in maintaining nervous system health. However, studies are often small, short-term, or industry-funded, and results can be mixed. There is less clear evidence for its use in healthy young adults or for specific neurological diseases. Overall, while phosphatidylserine is not universally endorsed as a treatment for neurological conditions, there is a moderate level of scientific evidence supporting its use for nervous system health, especially in the context of cognitive aging.