Evidence supporting the use of: Griffonia
For the body system: Nerves
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Griffonia simplicifolia is a plant native to West Africa, and its seeds are a natural source of 5-hydroxytryptophan (5-HTP), a direct precursor to the neurotransmitter serotonin. Serotonin plays a crucial role in regulating mood, sleep, and other neurological functions. Several scientific studies have investigated the effects of Griffonia seed extract—primarily standardized for 5-HTP—on neurological and psychological health.
Clinical trials and meta-analyses have found that 5-HTP supplementation can be moderately effective in alleviating symptoms of depression, anxiety, and insomnia, all of which are related to nervous system function. For example, a systematic review published in "Neuropsychiatric Disease and Treatment" (2012) concluded that 5-HTP showed potential in improving depressive symptoms, though the authors noted that larger and more rigorous studies are needed.
The mechanism underlying these effects is likely due to increased serotonin synthesis in the central nervous system, which is associated with improved mood and stress resilience. However, the majority of research has focused on 5-HTP in supplement form rather than Griffonia as a whole plant extract. While the evidence supports the use of Griffonia (via its 5-HTP content) in supporting the nervous system, particularly for mood and sleep, it is not considered robust or definitive. Therefore, the rating is moderate, reflecting promising but not conclusive scientific support.
Other ingredients that support Nerves
5-Hydroxytryptophan (5-HTP)acetyl l-carnitine
alfalfa
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
ashwagandha
waterhyssop
basil
beta caryophyllene
betel
black cohosh
sesame
bovine liver
broccoli
bасора
caffeine
calamari oil
calcium
California poppy
cannabis sativa oil
chamomile
chloride
choline
citicoline
coenzyme Q10 (CoQ10)
copper
cordyceps
cowage seed
turmeric
d-alpha tocopherol
damiana
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
eleuthero
feverfew
fish oil
fish protein
flavonols
folate
GABA (gamma aminobutyric acid)
gamma linolenic acid (GLA)
ginger
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
gotu kola
guarana
guayusa
hemp oil
hops
huperzine A
inositol
iron
jujube
kava root
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnitine
l-glycine
l-serine
l-phenylalanine
l-taurine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lecithin
lion's mane
mackerel
magnesium
magnolia
manganese
marine lipid
matcha
melatonin
milk
mint
motherwort
muira puama
Acetyl-L-Tyrosine
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oat
olive
omega-3 fatty acids
pantothenic acid (vitamin B5)
passionflower
peppermint oil
phosphatidylcholine
phosphatidylserine
phospholipids
phosphorus
phytocannabinoids
polygala root
potassium
protein
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
reishi mushroom
relora® (proprietary)
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
sceletium
black ginger
skullcap
spearmint leaf
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spinach
thiamin (vitamin B1)
almond fruit
valerian root
vegetable blend (proprietary)
velvet bean
vinpocetine
vitamin B
vitamin B12
vitamin B6
vitamin D
vitamin E
water
wild yam
yeast
zinc
β-nicotinamide mononucleotide (NMN)
suma
catnip
gastrodia
lobelia
mugwort
hedychium spicatum
peony
lingzhi
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kanna
silk tree
eucommia
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morinda
oriental arborvitae
zanthoxylum
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royal jelly
guelder rose
terpene lactones
polyphenols
trace minerals
purslane
camphor oil
menthol oil
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yerba mate
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noni
wood betony
hypothalamus
herbal blend (proprietary)
Sichuan pepper
yohimbe
cocoa
ashitaba
DMPX
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7,8-Dihydroxyflavone
Aralia
Avens
Antler
Asiaticoside
Angelica
Arachidonic Acid
Apigenin
Albizia
Alpha glyceryl
Aconite
Avocado
Anserina
Agmatine
Adrafinil
Acetylcholine
Agarwood
Anemone
Alpha-Lipoic Acid
Adrenaline
Animal protein
Betony
Bilobalide
Baikal Skullcap
Bleeding Heart
Biopterin
Black galingale
Beef
Beef liver
Bugbane
Baccosides
Bacopin
Baicalein
Benfotiamine
Black Gram
Brazil nut
Black willow
Brahmi
Bacopa
Broad Bean
Bee products
banana
bacoside
Baicalin
Black Hellebore
Bee venom
Borneol
Centrophenoxine
Coconut
Centella triterpenes
Caryophyllene
Clary sage
Cocarboxylase
Chinese Mountain Ant
Clerodendrum trichotomum
Catalpol
Cod Liver Oil
Curcuminoid
Canadine
Capsaicin
Cymbidium goeringii
Catecholamine
Cramp Bark
Chuchuhuasi
Calea zacatechichi
Centella asiatica
Coca
Chocolate
Capitate Valerian
Curcuma
Catuaba
Cowslip
Cannabidiol
Calamus
Convolvulus prostratus
Corydalis
Convolvulus Pluricaulis
Celastrus
Cytidine
cola nut
Canscora
Cannabichromene
Cannabigerol
Docosahexaenoic Acid
D-phenylalanine
Dicentra formosa
Dendrobium
Deer Velvet
Dihydrolipoic Acid
Dwarf Morning Glory
Dopamine
Date
Diterpenes
Deanol
Egg
Erythrina
Ergothioneine
Essential Oil Blend
Folic Acid
Flavin mononucleotide
Fo-Ti
Fish
Fatty acids
Flavones
fibroblast growth factor
Gelsemium
Ginsenosides
Galantamine
Griffonia simplicifolia
glucose
Ginkgolides
Ginkgo Flavone Glycoside
Ginkgoside
Glycolipids
Guaranine
Glycine
Ginkgoheteroside
Glutamic Acid
Gastrodin
jasmine
Lotus
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Poppy
Rose
Spikenard
Snakeroot (unspecified)
Shellfish
Squid
salt
Vervain
walnut
yohimbine
