Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gamma-linolenic acid (GLA) is an omega-6 fatty acid found in oils such as evening primrose, borage, and black currant seed oil. Its use to support the nervous system is primarily based on its role as a precursor to anti-inflammatory prostaglandins, which are thought to help modulate nerve function and inflammation. Scientific studies have particularly investigated GLA supplementation in the context of peripheral neuropathy, especially diabetic neuropathy. Some randomized controlled trials have demonstrated modest improvements in nerve function and symptomatic relief in patients with diabetic neuropathy who received GLA supplements, most notably in studies using evening primrose oil. However, results have been mixed, and meta-analyses suggest that while there may be a benefit, the magnitude is moderate and not all studies agree on efficacy.

The mechanism is believed to involve the restoration of deficient GLA levels in individuals with diabetes, potentially improving nerve conduction and reducing inflammatory damage to nerves. Despite some positive findings, the overall quality of evidence remains moderate, and major medical guidelines do not universally recommend GLA for neuropathy due to variability in study results and the need for larger, well-controlled trials. There is limited evidence for GLA supporting the nervous system outside of diabetic neuropathy. In summary, there is scientific rationale and some supportive evidence, but it is not robust, and benefits should be weighed against the current state of research.

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