Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fibroblast Growth Factors (FGFs) are a family of proteins involved in various biological processes, including cell growth, development, and tissue repair. In the context of the nervous system, certain FGFs—most notably FGF2 (basic FGF)—have been studied for their neurotrophic and neuroprotective properties. Scientific evidence from animal and in vitro studies suggests that FGFs can promote neuronal survival, stimulate nerve regeneration, and support neurogenesis, particularly following injury or in neurodegenerative disease models. For example, FGF2 has been shown to enhance survival of neurons after ischemic injury and participate in the regeneration of peripheral nerves. Furthermore, FGFs have roles in neural stem cell proliferation and differentiation, implying a potential for supporting nervous system repair.

However, while these findings are promising, most of the evidence comes from preclinical studies. Human clinical trials investigating the direct therapeutic use of FGFs for nervous system support are limited, and there are challenges related to delivery, safety, and specificity. FGFs are not generally used as dietary supplements for nerve health, but are being investigated as potential biologic therapies or drug targets. Overall, the scientific foundation for FGFs supporting the nervous system exists, but translation into clinical practice remains preliminary. Thus, the evidence is rated as moderate (3/5), reflecting promising but largely experimental support.

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