Amyloban is a standardized extract derived from the Lion’s Mane mushroom (Hericium erinaceus), particularly rich in compounds called amyloban and hericenones. It is used in supplements marketed for nervous system support, specifically targeting cognitive function and neurological health.

The scientific evidence supporting Amyloban’s use for the nervous system is limited but not absent. Some preclinical studies (in vitro and animal models) have shown that Lion’s Mane extracts can stimulate nerve growth factor (NGF) synthesis, which is vital for the maintenance, survival, and regeneration of neurons. A few small human clinical studies suggest potential benefits for mild cognitive impairment and mood, but these studies generally use Lion’s Mane extracts rather than the proprietary Amyloban extract, and often suffer from small sample sizes and short durations.

Research specifically on Amyloban is even more limited. A few studies, mostly from Japan, have investigated its use in cognitive decline and certain neurological conditions, but these are preliminary and not widely replicated. While there is a plausible biological mechanism and some initial clinical data, the overall quality and quantity of evidence are not robust. Therefore, while there is some scientific rationale for using Amyloban to support nervous system health, the current evidence base rates as modest (2/5).