Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 (methylcobalamin) is scientifically used to support or treat certain forms of nerve damage, particularly those associated with vitamin B12 deficiency. Methylcobalamin is an active form of B12 and plays a crucial role in the maintenance of the myelin sheath, which insulates nerve fibers. Deficiency in B12 can lead to neurological symptoms such as peripheral neuropathy, numbness, tingling, and even demyelination in severe cases. Clinical evidence supports the use of B12 supplementation for nerve damage in individuals with documented B12 deficiency, which can result from conditions like pernicious anemia, malabsorption syndromes, or prolonged vegetarian/vegan diets lacking fortified foods or supplements.

There is also some evidence from randomized controlled trials, particularly in diabetic neuropathy, that methylcobalamin may help reduce symptoms of neuropathy and improve nerve conduction, even in the absence of overt deficiency. A few studies suggest that high-dose methylcobalamin may improve nerve regeneration and sensory function, but these findings are not universally consistent, and the benefit in non-deficiency-related neuropathies remains less certain. Major guidelines recommend B12 supplementation for neuropathy only in the context of established deficiency. Overall, the evidence is strongest for deficiency-induced neuropathy, with weaker but suggestive evidence for broader neuropathic indications. The rating of 3 reflects moderate scientific support mainly for deficiency-associated nerve damage, with less robust evidence for use in other neuropathies.

More about Vitamin B12 (methylcobalamin)
More about Nerve Damage

Other ingredients used for Nerve Damage

Other health conditions supported by Vitamin B12 (methylcobalamin)

Products containing Vitamin B12 (methylcobalamin)