Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B12 (specifically its active forms, including 5-deoxyadenosylcobalamin) is scientifically validated for the treatment and prevention of nerve damage, particularly that caused by B12 deficiency. B12 is essential for the normal function of the nervous system, as it plays a key role in the synthesis of myelin, the protective sheath around nerves. Deficiency in B12 disrupts this process, leading to demyelination, which can result in neuropathy—manifesting as numbness, tingling, weakness, and balance problems. Clinical studies and case reports consistently show that supplementing B12 in individuals with deficiency improves or reverses neurological symptoms, especially if treatment is initiated early. B12 deficiency-related nerve damage is most commonly seen in individuals with pernicious anemia, malabsorption syndromes, or strict vegetarian/vegan diets. Randomized controlled trials and observational studies have demonstrated that B12 supplementation can halt progression and, in many cases, partially or fully restore nerve function. However, the benefit of B12 supplementation in individuals with normal B12 levels and nerve damage from other causes (e.g., diabetes, trauma) is less clear, and evidence does not support its widespread use for neuropathy unrelated to deficiency. In summary, there is robust scientific evidence supporting B12’s use for nerve damage specifically due to B12 deficiency, but not for other forms of neuropathy.

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