Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nicotinamide Adenine Dinucleotide (NAD⁺) and its precursors (such as nicotinamide riboside and nicotinamide mononucleotide) have been investigated for their potential neuroprotective effects and their role in supporting nerve health. NAD⁺ is a critical coenzyme involved in cellular energy metabolism and DNA repair. Several preclinical studies, particularly in animal models, have shown that boosting NAD⁺ levels can help reduce axonal degeneration and support nerve regeneration after injury. For example, research has demonstrated that increasing NAD⁺ availability via supplementation can delay Wallerian degeneration—a process of nerve fiber breakdown after injury—by activating protective pathways such as those involving SIRT1 and PARP enzymes. However, while these findings are promising in animal studies and some cellular models, robust clinical evidence in humans is currently limited. There are a few early-stage human studies and case reports suggesting potential benefits, but no large-scale, randomized controlled trials have definitively established NAD⁺ supplementation as an effective treatment for nerve damage in clinical settings. Thus, the scientific evidence supporting the use of NAD⁺ for treating or supporting nerve damage is preliminary and rated as modest (2/5), requiring further investigation before it can be widely recommended for this purpose.

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