Hericium mushroom, commonly known as Lion's Mane (Hericium erinaceus), is increasingly studied for its potential neuroregenerative properties. Scientific interest stems from the discovery that Lion's Mane contains compounds such as hericenones and erinacines, which have been shown in preclinical studies to stimulate the production of nerve growth factor (NGF). NGF is a protein crucial for the growth, maintenance, and survival of certain neurons. Animal studies have demonstrated that extracts of Hericium erinaceus can promote nerve regeneration after injury and may improve functional recovery in models of peripheral nerve damage. For example, a 2011 study in rats showed accelerated nerve regeneration and improved functional outcomes following administration of Lion’s Mane extract.

Human clinical research remains limited. A few small human trials suggest cognitive benefits in mild cognitive impairment, but direct evidence for treating or reversing nerve damage in humans is lacking. No large-scale randomized controlled trials have evaluated Hericium for this specific indication. While the mechanistic rationale and preclinical evidence are promising, clinical validation in humans is still preliminary. Therefore, the use of Hericium mushroom for nerve damage is supported by moderate scientific evidence based mainly on animal studies and mechanistic data, but more rigorous human research is needed before definitive conclusions can be drawn.