Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Rubia cordifolia, commonly known as Indian Madder or Manjistha, has been used in traditional Ayurvedic and Chinese medicine for various kidney-related ailments, including nephritis. In Ayurvedic texts, Manjistha is described as a "blood purifier" and is believed to have anti-inflammatory and detoxifying properties. Historically, it has been used in formulations to manage urinary disorders, kidney inflammation, and related symptoms, although the texts do not always specify the modern diagnosis of "nephritis."

From a scientific perspective, there are a limited number of preclinical studies suggesting possible anti-inflammatory and antioxidant effects of Rubia cordifolia extracts, which could theoretically be beneficial in kidney inflammation. For example, some studies have demonstrated that extracts from the plant may reduce markers of oxidative stress and inflammation in animal models. However, direct clinical evidence supporting its efficacy in treating nephritis in humans is lacking. Most of the evidence comes from traditional texts, ethnobotanical surveys, or in vitro and animal studies that do not directly address nephritis as defined in modern medicine.

In summary, the use of Rubia cordifolia for nephritis is primarily justified by traditional use, with some low-level scientific support for mechanisms that might be relevant to kidney inflammation. However, robust clinical trials in humans are absent, and the evidence level remains low.

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