Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoferrin is an iron-binding glycoprotein found in milk and other bodily secretions, with well-documented antimicrobial and immunomodulatory properties. Its use in nephritis, particularly in chronic kidney disease and glomerulonephritis, is supported by a modest but growing body of scientific evidence. Preclinical studies (mainly in animal models) have shown that lactoferrin can reduce inflammation, oxidative stress, and fibrosis in renal tissue. These effects are thought to result from its ability to modulate immune responses, inhibit pro-inflammatory cytokines, and limit iron-catalyzed free radical damage. One small randomized controlled trial in humans with chronic kidney disease suggested that oral lactoferrin supplementation might help reduce proteinuria and improve some markers of renal function, but data are limited and sample sizes are small.

There is no robust evidence base or large-scale clinical trials yet to firmly establish lactoferrin as a standard therapy for nephritis. However, its safety profile is favorable, and its pleiotropic effects (anti-inflammatory, antioxidant, and immunomodulatory) make it a promising adjunctive treatment under investigation. The current level of scientific validation is weak to moderate, primarily based on animal studies and preliminary clinical data, rather than extensive human research. Therefore, while not traditional, the scientific rationale for using lactoferrin in nephritis is plausible but not yet conclusive.

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