Evidence supporting the use of: Tetrahydrocannabinol
For the health condition: Nausea and Vomiting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Tetrahydrocannabinol (THC), the main psychoactive component of cannabis, has substantial scientific evidence supporting its use in the management of nausea and vomiting, particularly in patients undergoing chemotherapy. THC acts primarily as an agonist at the CB1 cannabinoid receptors in the central nervous system, which play a key role in modulating nausea and vomiting pathways. THC-based medications, such as dronabinol and nabilone, have received regulatory approval in several countries for the treatment of chemotherapy-induced nausea and vomiting (CINV) when standard antiemetic therapies are ineffective.

Numerous randomized controlled trials (RCTs) and meta-analyses have demonstrated that THC-containing cannabinoids are more effective than placebo and, in some cases, comparable to or better than traditional antiemetics in reducing CINV. For instance, a 2015 Cochrane review concluded that cannabinoids are useful for patients with CINV who do not respond to conventional antiemetic treatments. However, higher rates of adverse effects such as dizziness, dysphoria, and sedation are associated with THC use.

Although THC is less commonly used as a first-line therapy due to side effect concerns, its efficacy is well-documented for refractory cases. There is less robust evidence for its use in other forms of nausea and vomiting, such as those related to pregnancy or postoperative care, and these uses are not widely endorsed. Overall, the scientific validation for THC as a treatment for nausea and vomiting is strong, especially for chemotherapy-induced cases.

More about Tetrahydrocannabinol
More about Nausea and Vomiting

Other ingredients used for Nausea and Vomiting

Allspice
bamboo
myrobalan
benegut perilla (proprietary)
betel
black pepper
chamomile
chen pi
Coptis chinensis
fennel
fenugreek
ginger
gooseberry
jujube
kudzu
licorice root
lovage
mint
orange
Peppermint
phytocannabinoids
sage
spearmint leaf
vitamin B6
watermelon
chickweed
tangerine
typhonium
hyssop
cardamom
atractylodes
alpinia galangal
hedychium spicatum
anise
swertia
Szechuan lovage
prickly ash
root tuber
chrysanthemum
flowering quince
dogwood
dioscorea
sweetgums
caraway
camphor oil
yerba mate
peach
horehound
Sichuan pepper
soursop
sea salt
Apple Cider Vinegar
Agastache
Amomum
Asarum heterotropoides
Asafoetida
Agarwood
Asam gelugor
Angostura
Arrowroot
Agrimonia pilosa
Amor seco
Asarum sieboldii
Atractylone
Black Seed
Buttermilk
Blue Flag
Bryonia
Bai Ji
Balsam
Bael
Butternut
Baccharoides anthelmintica
Banyan
black salt
Black Nightshade
Buddha's Hand
Borassus aethiopum
Bitter principals
banana
Black Hellebore
Balloon Flower
Bottle gourd
Cumin
Centaury
Camellia sinensis
Chinese Silkvine
Clerodendrum trichotomum
Coriander
Cinquefoil
Cyathula
Citron
Carvone
Cymbopogon Martini
Coca
Cubeb
Chirata
Cannabidiol
Calamus
Colocynth
cola nut
Dill
Doxylamine succinate
Evodia
English Horsemint
Elephant's Head
Embelia
Fernbush
False Calumba
Goldthread
Gentian
Gentianella alborosea
Gentianopsis barbata
Giant Blazingstar
Homalomena
Indian Ipecac
Javanese Long Pepper
Kukicha
Kola Nut
Loquat
Lime
Large-leaf Gentian
Lesser speargrass
Linden
Lotus
Large-Leaved Linden
Little ironweed
Mentha haplocalyx
Mandarin
Marjoram
Marsh Tea
Mace
Malva sylvestris
Matapalo Tree
Meadowsweet
Nardostachys
Natsudaidai
Ophiopogon
Osmanthus
Phragmites
Piper chaba
Pulsatilla
Pepper Bark Tree
Phthalides
Piper retrofractum
Polygonatum
Pimpinella
Persimmon
Plectranthus amboinicus
Quince
Rue
Rubus
Rubiaceae
Rose
Rhus coriaria
Stephania root
Sensitive Plant
Southernwood
Savory
Scabrous Gentian
Sweet Bay
Sassafras
Sweet Orange alcohol
Tarragon
Vervain
Vanilla
Yuzu
Yellow Nut Sedge

Products containing Tetrahydrocannabinol

We currently have no products on Caring Sunshine that contain this ingredient.