Evidence supporting the use of: Doxylamine succinate
For the health condition: Nausea and Vomiting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Doxylamine succinate is scientifically validated for use in treating nausea and vomiting during pregnancy, particularly in combination with pyridoxine (vitamin B6). This specific combination is the active component in the FDA-approved medication Diclegis (in the U.S.) and Diclectin (in Canada), which are indicated for the management of nausea and vomiting of pregnancy (NVP) when conservative management fails. The evidence for this use is robust, stemming from multiple randomized controlled trials and decades of clinical experience, beginning with the use of a similar formulation (Bendectin) in the 1950s. Systematic reviews and meta-analyses have confirmed the efficacy and safety of doxylamine/pyridoxine for NVP, with a favorable risk profile, including no increased risk of birth defects. The American College of Obstetricians and Gynecologists (ACOG) and other professional bodies recommend this combination as a first-line pharmacologic therapy for NVP. However, it is important to note that doxylamine succinate alone (without pyridoxine) is not generally studied or used for nausea and vomiting outside of pregnancy, and its use for other causes of nausea is not supported by significant evidence. In summary, doxylamine succinate (with pyridoxine) is a scientifically validated and guideline-recommended treatment for nausea and vomiting of pregnancy.

More about Doxylamine succinate
More about Nausea and Vomiting

Other health conditions supported by Doxylamine succinate

Insomnia
Morning Sickness
Nausea and Vomiting
Sleep (restless and disturbed)

Products containing Doxylamine succinate

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