Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cannabidiol (CBD), a non-psychoactive compound found in cannabis, has been investigated for its potential antiemetic (anti-nausea and anti-vomiting) properties. There is moderate scientific evidence supporting its use for nausea and vomiting, particularly in the context of chemotherapy-induced symptoms. Preclinical studies indicate that CBD interacts with the endocannabinoid system, particularly the 5-HT1A serotonin receptor, which is implicated in the regulation of nausea and vomiting. Animal studies have demonstrated that CBD can suppress nausea and vomiting responses, and some human studies have also suggested benefit, especially when used in combination with tetrahydrocannabinol (THC). However, the majority of clinical research has focused on combined cannabinoid preparations (e.g., nabiximols) rather than CBD alone. The evidence for pure CBD in the management of nausea and vomiting in humans is more limited, but small clinical trials and anecdotal reports indicate potential efficacy, particularly in patients who do not respond to standard antiemetic therapy. Major guidelines and regulatory agencies generally recognize the use of cannabinoid-based medicines (including CBD/THC combinations) for refractory chemotherapy-induced nausea and vomiting, but not CBD in isolation. In summary, while there is a scientific rationale and some supportive evidence for the use of cannabidiol in treating nausea and vomiting, especially in specific contexts, more robust and high-quality human clinical trials are needed to establish its efficacy and optimal use.

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