Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Urolithin A is a metabolite produced by gut microbiota from ellagitannins found in foods like pomegranates and berries. Its use in the context of muscular dystrophy is based on preclinical, scientific evidence rather than traditional medicine. Several animal studies have explored Urolithin A’s potential to improve muscle function, with a key mechanism being the enhancement of mitophagy (the selective removal of damaged mitochondria) and mitochondrial biogenesis. In muscular dystrophy, mitochondrial dysfunction is thought to contribute to muscle degeneration. A 2019 study in Nature Medicine demonstrated that Urolithin A improved muscle function and mitochondrial health in mouse models of Duchenne muscular dystrophy. Similar findings were reported in other preclinical studies, where Urolithin A administration led to improved endurance, reduced muscle inflammation, and increased muscle strength in dystrophic mice. However, evidence in humans is currently lacking. Early-phase clinical trials in healthy older adults have shown that Urolithin A supplementation can improve markers of mitochondrial function and muscle health, but these results have not yet been extended to patients with muscular dystrophy. In summary, while there is promising scientific evidence from animal studies and mechanistic data suggesting Urolithin A could benefit muscular dystrophy patients, robust clinical trials in humans are still needed. The current rating of 2 reflects preliminary support that is not yet sufficient for routine clinical use.

More about Urolithin A
More about Muscular Dystrophy

Other ingredients used for Muscular Dystrophy

Other health conditions supported by Urolithin A

Products containing Urolithin A