Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Creatine supplementation has been investigated as a supportive therapy for muscular dystrophy, particularly Duchenne Muscular Dystrophy (DMD), based on its known role in cellular energy metabolism. Leucine, an essential branched-chain amino acid, is also of interest due to its capacity to stimulate muscle protein synthesis via activation of the mTOR pathway. Some research has explored the potential synergistic effects of creatine and leucine, though most studies have assessed them independently rather than as a combined “creatine-leucine” supplement.

Clinical studies on creatine in muscular dystrophy show modest but consistent benefits. Randomized controlled trials and meta-analyses (e.g., Tarnopolsky et al., 2004; Kley et al., 2013) suggest that creatine supplementation can improve muscle strength and function and may slow the progression of muscle weakness in DMD and other neuromuscular disorders. The safety profile is generally favorable, with few adverse effects reported.

Evidence for leucine alone or in combination with creatine is less robust. While leucine supplementation can help enhance muscle protein synthesis, direct evidence that it substantially benefits patients with muscular dystrophy is limited. Some preclinical studies and small trials suggest a possible positive effect, but further research is needed.

In summary, there is scientific evidence, primarily for creatine, supporting its use as an adjunct in the management of muscular dystrophy. The evidence rating is moderate (3/5), reflecting promising but not definitive results, especially for combined creatine-leucine supplementation.

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