Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Creatine has been studied as a supplement to support muscle function in individuals with Muscular Dystrophy (MD), particularly Duchenne Muscular Dystrophy (DMD). Several small clinical trials and systematic reviews have investigated creatine's effects in this population. Evidence suggests that creatine supplementation may result in modest improvements in muscle strength, lean body mass, and some aspects of physical function in children and adolescents with DMD. For example, a 2013 Cochrane review found that creatine supplementation led to small but statistically significant improvements in muscle strength and motor function, with no serious adverse effects reported in the short term.

Glutamine, on the other hand, has been studied far less extensively in the context of MD. Some small trials and animal studies have explored its potential for reducing muscle breakdown and supporting muscle metabolism, but results are inconsistent and generally do not show clear benefit in human MD patients. No robust, large-scale clinical trials have confirmed its efficacy for this purpose.

In summary, there is some scientific evidence—though limited and not unequivocal—supporting the use of creatine as an adjunct to standard care in muscular dystrophy, with a low-to-moderate level of evidence. Glutamine lacks sufficient evidence for efficacy in this context. Therefore, the use of creatine (but not glutamine) as a supportive therapy in MD is somewhat scientifically justified, but further research is needed to establish long-term safety and effectiveness.

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