Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Creatine supplementation has been studied as a supportive therapy in patients with muscular dystrophy, particularly Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD). The rationale is based on creatine’s role in cellular energy metabolism, specifically in replenishing ATP stores in muscle tissue. Several randomized controlled trials and meta-analyses (e.g., Clinical Rehabilitation, 2013; Neuromuscular Disorders, 2007) have shown that creatine supplementation can lead to modest improvements in muscle strength and function in some patients with muscular dystrophy. Reported benefits include increased fat-free mass, improved handgrip strength, and delayed muscle fatigue. However, the magnitude of effect is generally small and may not be clinically significant for all patients. Additionally, creatine appears to be well-tolerated with few adverse effects in these studies. Despite these positive findings, the evidence is not robust enough to warrant universal recommendation. Not all studies have demonstrated significant benefit, and sample sizes are often small. Major guidelines (such as those from the American Academy of Neurology) consider creatine a possible adjunct therapy but not a substitute for established treatments. In summary, creatine’s use in muscular dystrophy is scientifically supported by moderate-quality evidence, justifying a cautious but positive consideration as part of a broader management plan.

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