Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Withanolides are a group of naturally occurring steroidal lactones found primarily in plants of the genus Withania, such as Withania somnifera (Ashwagandha). Their use to support the muscular system is backed by a growing body of scientific evidence, though most studies are preclinical or involve small human trials. Research suggests that withanolides, particularly those from Ashwagandha, may enhance muscle strength, mass, and recovery. Several randomized, controlled trials in humans have shown that supplementation with Ashwagandha root extract can increase muscle mass and strength in young men engaged in resistance training. For example, a 2015 study published in the "Journal of the International Society of Sports Nutrition" found that participants taking Ashwagandha for eight weeks experienced significantly greater gains in muscle strength and size compared to placebo. The proposed mechanisms include withanolides’ anti-inflammatory, antioxidant, and adaptogenic effects, which may reduce exercise-induced muscle damage and improve recovery. Nonetheless, while results are promising, larger and longer-term clinical trials are needed to confirm efficacy and establish safety profiles. In summary, the use of withanolides to support muscle health is primarily justified by emerging scientific evidence, earning a moderate evidence rating.

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