Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin D (ergocalciferol) has a scientifically validated role in supporting the muscular system. Research shows that vitamin D is essential for muscle function because it facilitates calcium absorption and regulates calcium and phosphate balance, both critical for muscle contraction. Deficiency in vitamin D is associated with muscle weakness, increased risk of falls, and impaired muscle performance, particularly in older adults. Randomized controlled trials have demonstrated that vitamin D supplementation can improve muscle strength and physical performance in individuals with low vitamin D levels. Meta-analyses also support that vitamin D supplementation reduces fall risk in the elderly, likely due to its positive effects on muscle function.

The mechanism involves vitamin D receptors present on muscle cells; activation of these receptors influences muscle cell growth and function. While most evidence supports benefits in deficient or older populations, there is less evidence of benefit for muscle strength in individuals with sufficient vitamin D status. Nonetheless, the connection between vitamin D and muscle health is well established, and clinical guidelines recommend correcting vitamin D deficiency to support musculoskeletal health. The rating is not the highest because the benefit is most pronounced in deficient populations, and evidence in well-nourished, younger individuals is less robust.

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