Puerarin is an isoflavone compound extracted from the root of Pueraria lobata, commonly known as kudzu. Its traditional use, particularly in Chinese medicine, primarily revolves around its application for alleviating muscle stiffness, spasms, and pain, especially in conditions such as neck and upper back tension. Historical texts and modern Traditional Chinese Medicine (TCM) practices often cite kudzu root as a "muscle relaxant" and for promoting circulation in muscles. This traditional reputation is likely why Puerarin-containing products are sometimes marketed for muscle support.

However, scientific validation specific to muscle function, growth, or direct support is limited. Most research on Puerarin focuses on its cardiovascular, neuroprotective, and anti-inflammatory effects. While anti-inflammatory properties may indirectly benefit muscle recovery in situations of strain or injury, there is a lack of robust clinical research directly linking Puerarin supplementation to enhanced muscle health, strength, or performance in humans. Thus, the justification for its use in supporting the muscular system is rooted largely in traditional use rather than strong scientific evidence.