Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Potassium alpha-ketoisocaproate (KIC) is a metabolite of the branched-chain amino acid leucine. It has been studied for potential roles in supporting muscle metabolism and reducing muscle breakdown (catabolism), particularly in catabolic states like exercise or illness. KIC is sometimes used in medical foods for patients with chronic kidney disease due to its ability to provide nitrogen without adding to the urea load. In the realm of sports and muscle support, some studies suggest that KIC, particularly when combined with other amino acids (e.g., HMB or glutamine), may help reduce markers of muscle damage and enhance recovery after intense exercise. However, the evidence is mixed, with some clinical trials showing minimal or no effect on muscle performance or hypertrophy in healthy individuals. The proposed mechanism involves KIC serving as an alternative energy substrate during exercise and modulating ammonia levels, potentially reducing muscle fatigue. Overall, while there is some scientific investigation into KIC's use for muscle support, the quality and quantity of evidence are moderate, and it is not as well-supported as other supplements like creatine or essential amino acids. More rigorous research is needed to clarify its efficacy for muscle health in both clinical and athletic populations.

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