Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nicotinamide riboside (NR) is a form of vitamin B3 and a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule essential for cellular metabolism and energy production. The rationale for using NR to support the muscular system is based on its ability to increase NAD+ levels, which may help maintain mitochondrial function and muscle health, especially during aging.

Preclinical studies in rodents have shown that NR supplementation can enhance muscle regeneration after injury and improve mitochondrial function in skeletal muscle. For example, animal studies have demonstrated increased endurance and reduced muscle degeneration with NR supplementation in models of muscular dystrophy and aging. A few small human studies suggest NR can increase NAD+ levels in muscle tissue, but evidence for direct improvements in muscle strength or performance is limited and inconsistent.

Currently, there is insufficient robust clinical evidence to confirm that NR supplementation leads to significant, meaningful improvements in muscle mass, strength, or function in healthy adults or those with muscle-related conditions. Most of the supportive data comes from animal studies or basic research on cellular mechanisms, with only preliminary data in humans. Therefore, while there is scientific rationale and early evidence supporting NR for muscle health, current evidence level is low to moderate (rated 2/5), and more well-controlled human trials are needed.

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