Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ligandrol (LGD-4033) is a selective androgen receptor modulator (SARM) that has been investigated primarily for its potential to increase lean muscle mass and strength. Scientific validation for its use in supporting the muscle system comes from several clinical trials and preclinical studies. For example, a double-blind, placebo-controlled Phase I trial published in 2013 demonstrated that healthy men taking Ligandrol for 21 days experienced dose-dependent increases in lean body mass compared to placebo, without significant adverse effects. These effects are attributed to Ligandrol's selective activation of androgen receptors in muscle and bone, promoting anabolic activity while minimizing the androgenic side effects commonly associated with anabolic steroids.

However, the evidence is not robust enough for a higher rating because most studies have been short-term, involved small sample sizes, and focused on healthy volunteers rather than clinical populations such as those with muscle wasting disorders. Long-term safety and efficacy data are lacking, and Ligandrol is not approved for medical use anywhere in the world. Additionally, Ligandrol is classified as a prohibited substance by the World Anti-Doping Agency (WADA) due to concerns about misuse in sports. In summary, while there is scientific evidence supporting Ligandrol's potential to increase muscle mass, more comprehensive studies are required to fully validate its safety and therapeutic effectiveness.

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