Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-threonine is an essential amino acid that plays a key role in protein synthesis and is necessary for the proper functioning of muscles and other tissues. Its scientific justification for supporting the muscular system is based on its biological role: muscles require amino acids to repair, grow, and maintain muscle fibers, especially after exercise or periods of increased physical activity. L-threonine is one of the building blocks of muscle proteins such as collagen and elastin, which are integral for muscle structure and function.

However, while there is strong evidence that a deficiency in L-threonine results in impaired growth and muscle function (as shown in animal and human studies), there is limited direct evidence that supplementation with L-threonine specifically enhances muscle health, strength, or recovery in individuals who already consume adequate dietary protein. Most studies focus on general protein or amino acid supplementation rather than L-threonine alone. In clinical nutrition, L-threonine is included in formulations for patients with malnutrition or increased protein needs, indirectly supporting muscle maintenance.

In summary, while the biological necessity of L-threonine for muscle protein synthesis is well-established, direct evidence for supplementation benefits in the general population is limited. Its use to support the muscle system is scientifically plausible and justified primarily by its fundamental role as an essential amino acid, warranting a moderate evidence rating.

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