Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ketosterones, particularly those derived from the plant Eurycoma longifolia (Tongkat Ali) or from Ecdysteroid-containing plants like Rhaponticum carthamoides (Leuzea), have a history of traditional use for supporting muscle health and physical performance. In traditional medicine systems, such as those in Southeast Asia and Russia, plant extracts rich in ketosterones (notably ecdysteroids) have been used to promote vitality, increase strength, and aid in muscle recovery, especially among athletes and laborers. The rationale for their use is based on anecdotal reports and ethnobotanical records that associate these compounds with improved endurance and muscle function.

However, scientific validation for these effects is limited and preliminary. Some animal and in vitro studies suggest that ecdysteroids may have anabolic effects—stimulating protein synthesis and muscle growth—without the androgenic side effects associated with anabolic steroids. Human studies are sparse and often methodologically weak or inconclusive. The available evidence does not robustly confirm significant benefits for muscle growth or strength in humans. Most claims are extrapolated from traditional practices or early-stage research, rather than from rigorous clinical trials. Therefore, while there is a traditional basis for using ketosterones to support the muscles body system, the overall evidence is weak, and more high-quality human studies are needed to substantiate these claims.

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