Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glutamine, an amino acid commonly described as a "glutamine precursor," is involved in many metabolic processes, including serving as a building block for protein synthesis in muscle tissue. Its popularity as a sports supplement is based on the theory that intense exercise can decrease plasma glutamine levels, which may impair muscle recovery or immune function. Some small studies have suggested that glutamine supplementation may help reduce muscle soreness and improve muscle recovery after intense exercise. However, the overall scientific evidence is limited and mixed. Several systematic reviews and randomized controlled trials have found little to no significant benefit of glutamine supplementation for muscle growth, strength, or recovery in healthy adults or athletes when compared to placebo. The body can synthesize sufficient glutamine under most conditions, and deficiencies are rare except in cases of severe trauma or illness. Therefore, while glutamine is important for muscle metabolism, supplemental glutamine or its precursors do not have robust evidence supporting their use for enhancing muscle performance or recovery in healthy individuals. In summary, there is a scientific rationale for glutamine's role in the body, but the evidence supporting the use of glutamine precursors specifically for muscle support is weak.

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