Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Coenzyme Q10 (CoQ10) has a scientific rationale for use in supporting the muscular system, primarily due to its role in mitochondrial energy production. CoQ10 is an essential component of the electron transport chain, facilitating ATP synthesis—the main energy source for muscle contraction. Several clinical studies have investigated its benefits in individuals with muscle-related conditions. For example, patients with statin-induced myopathy (muscle pain caused by cholesterol-lowering drugs) have shown modest improvements in symptoms with CoQ10 supplementation, though results are mixed and not universally conclusive. Additionally, CoQ10 deficiency has been linked to certain rare myopathies, and supplementation may help in these contexts. In athletes and healthy individuals, CoQ10 supplementation has been studied for potential improvements in exercise performance, muscle fatigue, and recovery. Some studies report slight enhancements in exercise capacity and reduced markers of muscle damage, but the effects are generally small. Overall, while CoQ10’s role in muscle energy metabolism is well-established biochemically, the clinical evidence for supplementation benefiting muscle strength or function in healthy individuals is moderate at best (hence, a rating of 3). It is more strongly supported for specific populations experiencing muscle dysfunction related to statin use or mitochondrial disorders, rather than for general muscle support.

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