Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Calcium hydroxyisocaproate (also known as Calcium HMB or calcium β-hydroxy β-methylbutyrate) is a well-studied supplement for supporting muscle health. HMB is a metabolite of the amino acid leucine, which plays a crucial role in muscle protein synthesis and the reduction of muscle protein breakdown. Scientific research, including randomized controlled trials, has demonstrated that HMB supplementation can help preserve muscle mass and strength, particularly in individuals experiencing muscle wasting due to aging (sarcopenia), prolonged inactivity, or illness. It has also been shown to augment muscle gains and reduce muscle damage in athletes and people starting resistance training.

The majority of evidence comes from studies using the calcium salt form of HMB, given its stability and bioavailability. Meta-analyses have found statistically significant effects of HMB (including Calcium HMB) on muscle strength and lean body mass, especially in older adults and clinical populations. However, the effects are often more modest in healthy, well-trained individuals. Mechanistically, HMB appears to attenuate muscle protein breakdown and support muscle repair by influencing pathways involved in muscle cell integrity and recovery.

In summary, the use of calcium hydroxyisocaproate to support the muscle system is backed by scientific evidence, particularly in specific populations at risk of muscle loss. Its use is justified by multiple clinical studies, though the magnitude of its benefit can vary depending on the population and context.

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