Evidence supporting the use of: Arginine silicate
For the body system: Muscles
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Arginine silicate is a compound composed of the amino acid L-arginine and silicon, often marketed for its potential benefits in supporting muscle and vascular health. The rationale for its use in the muscle body system primarily centers on the role of L-arginine as a precursor to nitric oxide (NO), a molecule involved in vasodilation and blood flow regulation. Enhanced blood flow is theorized to support nutrient and oxygen delivery to muscles during exercise, potentially aiding performance and recovery. A few small-scale clinical studies have examined arginine silicate (often in the form of arginine silicate inositol, or ASI), suggesting that it can increase plasma arginine levels and, in some cases, enhance markers of muscle pump and perceived performance during resistance exercise. However, evidence remains limited, with most studies involving relatively small sample sizes, short durations, and sometimes lacking rigorous controls. Reviews highlight that while arginine supplementation may improve blood flow, the magnitude of effect on muscle function or growth is modest and not consistently demonstrated. There is little tradition of arginine silicate use specifically for muscle support; its use is driven by recent scientific interest rather than historical precedent. In summary, while there is some scientific basis for arginine silicate’s role in supporting muscle function via increased nitric oxide production, the evidence is moderate at best, warranting a rating of 2 out of 5.
Other ingredients that support Muscles
acetyl l-carnitineadenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
astaxanthin
beet
beta-alanine
bovine
bovine liver
branched-chain amino acids
bromelain
caffeine
calcium
cherry
chloride
coenzyme Q10 (CoQ10)
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
turmeric
d-alpha tocopherol
devil's claw
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fish protein
forskohlii root
l-isoleucine
iron
kale
l-alanine
l-alanyl-l-glutamine
l-arginine
l-carnitine
l-carnosine
l-citrulline
l-glutamine
l-glycine
l-leucine
l-ornithine
l-proline
l-taurine
l-threonine
l-valine
magnesium
malic acid
maltodextrin
maltose
methylsulfonylmethane (MSM)
milk
nicotinamide riboside
ornithine alpha-ketoglutarate
peppermint oil
phosphorus
phytocannabinoids
potassium
protein
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sardines
black ginger
soybean
specialized pro-resolving mediators (SPMs)
spinach
spirulina
tongkat ali
ubiquinol
Urolithin A
vitamin B
vitamin C
vitamin D
vitamin D3
water
watermelon
whey protein
white willow
β-nicotinamide mononucleotide (NMN)
suma
squawvine
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solomon's seal
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eucommia
electrolytes blend (proprietary)
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trace minerals
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Arginine Alpha Ketoglutarate
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Antler
Arginine Creatine
Arginine nitrate
Arachidonic Acid
Arginine malate
Arginine aspartate
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Anserina
Alpha-ketoisocaproic acid
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adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine alpha-ketoisocaproate
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Animal protein
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Biopeptide
Beta-hydroxybutyrate
Bicarbonate
Beef Protein
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Beef liver
Bovine Protein
Black Gram
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Bee products
banana
BCAA
Chia seed
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Cardarine
Chinese Mountain Ant
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Citrate malate
Cyathula
Curcuminoid
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Cyanotis Vaga
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Coconut Water
Cetylated Fatty Acids
Creatine
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Curcuma
C-Phycocyanin
Cyanotis arachnoides
DL-Methionine
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Dipsacus
Dipeptide
Egg
Elk antler
Emu Oil
Ecdysteroids
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Egg protein
Glycine
Isoleucine
Milk Protein
Phosphate Salt
Potash
Quinoa Protein
salt
Soy Protein