Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-ketoisocaproic acid (KIC) is a keto acid derived from the metabolism of the branched-chain amino acid leucine. It has been studied for its potential to support muscle metabolism, particularly in the context of exercise and muscle wasting conditions. Scientific investigations suggest that KIC can act as an intermediate in amino acid metabolism and may help spare muscle protein by serving as an alternative substrate for energy production. Some studies indicate that supplementation with KIC, either alone or in combination with other compounds such as beta-hydroxy beta-methylbutyrate (HMB) or glycine, may reduce markers of muscle protein breakdown, improve nitrogen balance, or enhance exercise performance in specific populations (e.g., athletes or individuals with muscle-wasting diseases).

However, the magnitude and consistency of these effects are modest. Not all studies have shown significant benefits, and the evidence base is relatively limited compared to more established supplements like creatine or protein. The use of KIC is primarily justified by its biochemical role in leucine metabolism and preliminary human trials, but large-scale, long-term studies are lacking. Therefore, while there is some scientific rationale and moderate preliminary evidence for its use in supporting muscle health, it is not universally endorsed or considered a first-line supplement for muscle support.

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