Synopsis

Source of validity: Scientific
Rating (out of 5): 4

2a, 17a-dimethyl-17b-hydroxy-5a-androstan-3-one is better known as mestanolone, a synthetic anabolic-androgenic steroid (AAS) derived from dihydrotestosterone (DHT). Its use to support the muscle system is based on its anabolic properties—specifically, its ability to promote muscle growth, enhance strength, and improve physical performance. Mestanolone has been studied and used since the 1950s in both medical and athletic contexts, although its use is now largely restricted due to potential for abuse and adverse effects.

Scientifically, mestanolone binds to androgen receptors, stimulating protein synthesis and muscle hypertrophy. Studies on similar anabolic steroids demonstrate increased lean muscle mass and strength in both clinical and athletic settings. While direct controlled trials on mestanolone in healthy populations are limited, animal studies and clinical data from related AAS provide a strong mechanistic rationale for its muscle-supporting effects. In practice, it was used in medicine for treating conditions involving muscle wasting, though safer alternatives are now preferred.

Widespread non-medical use by athletes, especially in the mid-20th century, further supports the tradition of its muscle-building capacity, though such use is now banned by most sporting authorities. The main limitation to its wider acceptance arises from its risk profile, including liver toxicity and androgenic side effects. In conclusion, mestanolone’s use to support the muscle system is scientifically validated, though not recommended outside supervised medical settings due to safety concerns.

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