Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ursolic acid is a naturally occurring compound found in many plants, including apple peels, rosemary, and basil. Its use for supporting or improving muscle tone is primarily grounded in preclinical scientific research rather than traditional medicine. Several animal studies, particularly in mice, have indicated that ursolic acid supplementation can increase skeletal muscle mass and strength. These effects appear to be mediated through enhanced insulin/IGF-1 signaling, reduced muscle atrophy, and increased muscle protein synthesis. For instance, a 2011 study published in Cell Metabolism demonstrated that ursolic acid supplementation prevented muscle atrophy and stimulated muscle growth in mice models. There is also evidence suggesting that ursolic acid may decrease fat accumulation, which could indirectly support improved muscle tone or composition.

However, evidence from human studies is limited. Few clinical trials have evaluated the effects of ursolic acid on muscle mass or strength in humans, and the available studies are often small and preliminary. Some early human trials have reported modest benefits in muscle hypertrophy and strength when combined with resistance exercise, but these findings have not been widely replicated and further research is needed. Therefore, while the scientific rationale is promising and animal data are supportive, the evidence base in humans is not robust, leading to a moderate-low evidence rating overall.

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