Evidence supporting the use of: L-valine
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-valine is an essential branched-chain amino acid (BCAA) that, along with leucine and isoleucine, plays a role in muscle metabolism and maintenance. Its use to support muscle tone, especially in cases of muscle wasting or lack of muscle tone, is primarily based on its biochemical role in protein synthesis and muscle repair. Some clinical studies have shown that BCAA supplementation — including L-valine — may help reduce muscle breakdown and support muscle maintenance in specific populations, such as athletes during intense training or individuals with muscle wasting due to illness. However, the evidence is not robust or specific to L-valine alone; most research examines BCAAs as a group, and the contribution of valine compared to leucine (the most studied BCAA) is less clear. The clinical benefit of supplementation in healthy individuals or those with mild muscle tone issues is not well established, and more research is needed to determine efficacy and optimal dosing. Thus, while there is a scientific rationale and some clinical evidence supporting its use for muscle tone, the strength of evidence is modest and primarily extrapolated from studies on BCAAs generally rather than L-valine specifically.

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Other health conditions supported by L-valine

Athletic and Exercise Aids
Body Building
Fatigue
Muscle Tone (lack of)