Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D is supported by scientific evidence for its use in managing Multiple Sclerosis (MS), though the evidence is moderate and not definitive. Epidemiological studies have long observed that MS prevalence is higher in regions with less sunlight exposure, suggesting a role for vitamin D. Biologically, vitamin D is involved in immune modulation, influencing T-cell and macrophage activity, which are central to MS pathogenesis. Observational studies have found that lower serum vitamin D levels are associated with increased risk of MS onset and relapses. Some interventional trials suggest that vitamin D supplementation might reduce relapse rates or MRI lesion activity in MS patients, but results are mixed and often limited by small sample sizes and variability in dosing regimens. Major neurological societies, including the National Multiple Sclerosis Society, acknowledge that vitamin D supplementation is reasonable for people with MS, especially to maintain normal serum levels, though it is not recommended as a standalone therapy. Large-scale, well-controlled randomized trials are ongoing to clarify its clinical benefits. In summary, vitamin D is not a cure, but its use in MS is grounded in scientific rationale and moderate-quality evidence, primarily for immune system support and potentially for reducing disease activity.

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